Education of today is faced by challenges and innovations. The key area where innovations are pronounced is Instructional Methodology. It becomes necessary for the teachers and educators to incorporate new trends and methodologies in instructional methodology. One such aspect that came into existence is Intelligent Tutorial System (ITS). The introduction of Artificial Intelligence techniques and Expert Systems technology to CAI systems gave rise to Intelligent Tutoring Systems (ITS). ITS can model the learner’s understanding of a topic and adapt the instruction accordingly. An ITS is a learning system that is capable to analyze learners knowledge from their performances on exercises or tests so that the system can provide appropriate learning contents to individual learner. The present book provides an in-depth understanding about Artificial Intelligence (AI), Expert Systems, Intelligent Tutoring System (ITS), Learning Theories supporting to ITS, Architecture of different types of Intelligent Tutorial System, Development of ITS, Collaborative Inquiry Tutors, ITS based Mobile Learning and Online Learning and several other issues concerning ITS. It discusses the pedagogical aspects in detail and focuses on the role of educators and teachers in developing the ITS-based learning environment for the learners.